Genasense (oblimersen sodium)
By Business Review Editor
Pharma Deals Review: Vol 2007 Issue 88 (Table of Contents)
Published: 7 Oct-2007
DOI: 10.3833/pdr.v2007.i88.273 ISSN: 1756-7874
Section: Deal Trackers
Fulltext:
Abstract
Genasense® (oblimersen sodium) is an antisense oligonucleotide (ASO) developed by Genta for systemic use as an injection. It comprises a phosphorothioate backbone linking 18 modifi ed DNA bases, and targets the fi rst six codons of BCL-2 mRNA to form a DNA/RNA complex, which is subsequently recognised as foreign and cleaved enzymatically...
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